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<span id="openzim-page-title" class="mw-page-title-main"><span class="mw-page-title-main">PSTPIP1</span></span>
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<table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">PSTPIP1</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Available structures</th></tr><tr><th rowspan="2" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;width:43px"><a href="Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit">Ortholog search: <span class=""><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=P97814%20or%20O43586%20or%20H0YLM9">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:P97814,O43586,H0YLM9">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="text-align:center"><th colspan="2" style="background-color:light-dark(#ddd, #404244) !important;color:inherit">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><p><span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2DIL">2DIL</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Identifiers</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><span class=""><a href="Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:light-dark(#eee, #27292d) !important;color:inherit"><span class=""><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/9580">PSTPIP1</a></span>, CD2BP1, CD2BP1L, CD2BP1S, H-PIP, PAPAS, PSTPIP, proline-serine-threonine phosphatase interacting protein 1</td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">External IDs</th><td colspan="3" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class=""><a href="Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/606347">606347</a>; <a href="Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:1321396">1321396</a>; <a href="HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=37867">37867</a>; <a href="GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=PSTPIP1">PSTPIP1</a>; <a href="Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000140368">PSTPIP1 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class=""><a href="Chromosome_15_(human)" class="mw-redirect" title="Chromosome 15 (human)">Chromosome 15 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"></span><div style="position: absolute; left: 216.70537276455px; top: 2px; padding: 0;"><span typeof="mw:File"></span></div><div style="position: absolute; left: 222.7px; top: 19px; padding: 0;"><span typeof="mw:File"></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">15q24.3</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">76,993,359 <a href="Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">77,037,475 <a href="Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">Chromosome 9 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"></span><div style="position: absolute; left: 126.8393300318px; top: 2px; padding: 0;"><span typeof="mw:File"></span></div><div style="position: absolute; left: 132.8px; top: 19px; padding: 0;"><span typeof="mw:File"></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">9|9 B</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">55,997,246 <a href="Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">56,036,172 <a href="Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="Human_genome" title="Human genome">Human</a></b></th><th><b><a href="Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000140368">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">granulocyte</li><br><li style="line-height: 137%;">monocyte</li><br><li style="line-height: 137%;">blood</li><br><li style="line-height: 137%;">spleen</li><br><li style="line-height: 137%;">bone marrow cell</li><br><li style="line-height: 137%;">lymph node</li><br><li style="line-height: 137%;">appendix</li><br><li style="line-height: 137%;">tendon of biceps brachii</li><br><li style="line-height: 137%;">Achilles tendon</li><br><li style="line-height: 137%;">upper lobe of left lung</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000032322">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">granulocyte</li><br><li style="line-height: 137%;">thymus</li><br><li style="line-height: 137%;">blood</li><br><li style="line-height: 137%;">stroma of bone marrow</li><br><li style="line-height: 137%;">mesenteric lymph nodes</li><br><li style="line-height: 137%;">molar</li><br><li style="line-height: 137%;">tibiofemoral joint</li><br><li style="line-height: 137%;">primary oocyte</li><br><li style="line-height: 137%;">gastric mucosa</li><br><li style="line-height: 137%;">mucous cell of stomach</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class=""><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000140368">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class=""><a rel="nofollow" class="external text" href="http://biogps.org/gene/9051/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Molecular function</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="">
<ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042802">identical protein binding</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008092">cytoskeletal protein binding</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051015">actin filament binding</a></li></ul>
</div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Cellular component</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="">
<ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">cytoplasm</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048471">perinuclear region of cytoplasm</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005829">cytosol</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li>
<li><a href="https://www.wikidata.org/wiki/Q1328679" class="extiw external" title="d:Q1328679">uropod</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032154">cleavage furrow</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042995">cell projection</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005856">cytoskeleton</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030027">lamellipodium</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005884">actin filament</a></li></ul>
</div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Biological process</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="">
<ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007155">cell adhesion</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006954">inflammatory response</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006897">endocytosis</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007165">signal transduction</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002376">immune system process</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045087">innate immune response</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030041">actin filament polymerization</a></li>
<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016477">cell migration</a></li></ul>
</div></td></tr><tr><td colspan="4" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=9051&rn=1">9051</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=19200&rn=1">19200</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000140368;db=core">ENSG00000140368</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000032322;db=core">ENSMUSG00000032322</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/O43586">O43586</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P97814">P97814</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class=""></th></tr><tr><td colspan="1"><p><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_003978">NM_003978</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001321135">NM_001321135</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001321136">NM_001321136</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001321137">NM_001321137</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class=""></th></tr><tr><td colspan="1"><p><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_011193">NM_011193</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class=""></th></tr><tr><td colspan="1"><p><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001308064">NP_001308064</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001308065">NP_001308065</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001308066">NP_001308066</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_003969">NP_003969</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class=""></th></tr><tr><td colspan="1"><p><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_035323">NP_035323</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Location (UCSC)</th><td><span class=""><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr15:76993359-77037475">Chr 15: 76.99 – 77.04 Mb</a></span></td><td><span class=""><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr9:55997246-56036172">Chr 9: 56 – 56.04 Mb</a></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="PubMed" title="PubMed">PubMed</a> search</th><td><span class=""><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class=""><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><a href="Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q18033787" class="extiw external" title="d:Q18033787">View/Edit Human</a></td><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q18253296" class="extiw external" title="d:Q18253296">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table>
<p><b>Proline-serine-threonine phosphatase-interacting protein 1</b> is an <a href="Enzyme" title="Enzyme">enzyme</a> that in humans is encoded by the <i>PSTPIP1</i> <a href="Gene" title="Gene">gene</a>.<sup id="cite_ref-pmid9857189_5-0" class="reference"><a href="#cite_note-pmid9857189-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-entrez_6-0" class="reference"><a href="#cite_note-entrez-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup>
</p>
<meta property="mw:PageProp/toc">
<div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2></div>
<p>PSTPIP1 has been shown to <a href="Protein-protein_interaction" class="mw-redirect" title="Protein-protein interaction">interact</a> with:
</p>
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<ul><li><a href="Abl_gene" class="mw-redirect" title="Abl gene">Abl gene</a><sup id="cite_ref-pmid11163214_7-0" class="reference"><a href="#cite_note-pmid11163214-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup></li>
<li><a href="BZW1" title="BZW1">BZW1</a><sup id="cite_ref-pmid17353931_8-0" class="reference"><a href="#cite_note-pmid17353931-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup></li>
<li><a href="CD2" title="CD2">CD2</a><sup id="cite_ref-pmid9857189_5-1" class="reference"><a href="#cite_note-pmid9857189-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup></li>
<li><a href="PTPN12" title="PTPN12">PTPN12</a><sup id="cite_ref-pmid9422760_9-0" class="reference"><a href="#cite_note-pmid9422760-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li>
<li><a href="PTPN18" title="PTPN18">PTPN18</a><sup id="cite_ref-pmid9265651_10-0" class="reference"><a href="#cite_note-pmid9265651-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup></li>
<li><a href="Wiskott%E2%80%93Aldrich_syndrome_protein" title="Wiskott–Aldrich syndrome protein">Wiskott–Aldrich syndrome protein</a><sup id="cite_ref-pmid9488710_11-0" class="reference"><a href="#cite_note-pmid9488710-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup></li></ul>
</div>
<div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2></div>
<ul><li><a href="PAPA_syndrome" title="PAPA syndrome">PAPA syndrome</a></li></ul>
<div class="mw-heading mw-heading2"><h2 id="References">References</h2></div>
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<li id="cite_note-pmid9265651-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid9265651_10-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFSpencerDowbenkoChengLi1997" class="citation journal cs1">Spencer S, Dowbenko D, Cheng J, Li W, Brush J, Utzig S, Simanis V, Lasky LA (August 1997). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138048">"PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase"</a>. <i>J. Cell Biol</i>. <b>138</b> (4): <span class="nowrap">845–</span>60. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1083%2Fjcb.138.4.845">10.1083/jcb.138.4.845</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138048">2138048</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9265651">9265651</a>.</cite></span>
</li>
<li id="cite_note-pmid9488710-11"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid9488710_11-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFWuSpencerLasky1998" class="citation journal cs1">Wu Y, Spencer SD, Lasky LA (March 1998). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.273.10.5765">"Tyrosine phosphorylation regulates the SH3-mediated binding of the Wiskott–Aldrich syndrome protein to PSTPIP, a cytoskeletal-associated protein"</a>. <i>J. Biol. Chem</i>. <b>273</b> (10): <span class="nowrap">5765–</span>70. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.273.10.5765">10.1074/jbc.273.10.5765</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9488710">9488710</a>.</cite></span>
</li>
</ol></div></div>
<div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2></div>
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<ul><li><cite id="CITEREFSpencerDowbenkoChengLi1997" class="citation journal cs1">Spencer S, Dowbenko D, Cheng J, Li W, Brush J, Utzig S, Simanis V, Lasky LA (1997). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138048">"PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase"</a>. <i>J. Cell Biol</i>. <b>138</b> (4): <span class="nowrap">845–</span>60. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1083%2Fjcb.138.4.845">10.1083/jcb.138.4.845</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138048">2138048</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9265651">9265651</a>.</cite></li>
<li><cite id="CITEREFDowbenkoSpencerQuanLasky1998" class="citation journal cs1">Dowbenko D, Spencer S, Quan C, Lasky LA (1998). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.273.2.989">"Identification of a novel polyproline recognition site in the cytoskeletal associated protein, proline serine threonine phosphatase interacting protein"</a>. <i>J. Biol. Chem</i>. <b>273</b> (2): <span class="nowrap">989–</span>96. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.273.2.989">10.1074/jbc.273.2.989</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9422760">9422760</a>.</cite></li>
<li><cite id="CITEREFWuSpencerLasky1998" class="citation journal cs1">Wu Y, Spencer SD, Lasky LA (1998). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.273.10.5765">"Tyrosine phosphorylation regulates the SH3-mediated binding of the Wiskott–Aldrich syndrome protein to PSTPIP, a cytoskeletal-associated protein"</a>. <i>J. Biol. Chem</i>. <b>273</b> (10): <span class="nowrap">5765–</span>70. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.273.10.5765">10.1074/jbc.273.10.5765</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9488710">9488710</a>.</cite></li>
<li><cite id="CITEREFWuDowbenkoLasky1998" class="citation journal cs1">Wu Y, Dowbenko D, Lasky LA (1998). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.273.46.30487">"PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase"</a>. <i>J. Biol. Chem</i>. <b>273</b> (46): <span class="nowrap">30487–</span>96. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.273.46.30487">10.1074/jbc.273.46.30487</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9804817">9804817</a>.</cite></li>
<li><cite id="CITEREFCongSpencerCôtéWu2000" class="citation journal cs1">Cong F, Spencer S, Côté JF, Wu Y, Tremblay ML, Lasky LA, Goff SP (2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS1097-2765%2800%2900138-6">"Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation"</a>. <i>Mol. Cell</i>. <b>6</b> (6): <span class="nowrap">1413–</span>23. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS1097-2765%2800%2900138-6">10.1016/S1097-2765(00)00138-6</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11163214">11163214</a>.</cite></li>
<li><cite id="CITEREFOdaOchsLaskySpencer2001" class="citation journal cs1">Oda A, Ochs HD, Lasky LA, Spencer S, Ozaki K, Fujihara M, Handa M, Ikebuchi K, Ikeda H (2001). <a rel="nofollow" class="external text" href="https://doi.org/10.1182%2Fblood.V97.9.2633">"CrkL is an adapter for Wiskott–Aldrich syndrome protein and Syk"</a>. <i>Blood</i>. <b>97</b> (9): <span class="nowrap">2633–</span>9. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1182%2Fblood.V97.9.2633">10.1182/blood.V97.9.2633</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11313252">11313252</a>.</cite></li>
<li><cite id="CITEREFCôtéChungThébergeHallé2002" class="citation journal cs1">Côté JF, Chung PL, Théberge JF, Hallé M, Spencer S, Lasky LA, Tremblay ML (2002). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M106428200">"PSTPIP is a substrate of PTP-PEST and serves as a scaffold guiding PTP-PEST toward a specific dephosphorylation of WASP"</a>. <i>J. Biol. Chem</i>. <b>277</b> (4): <span class="nowrap">2973–</span>86. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M106428200">10.1074/jbc.M106428200</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11711533">11711533</a>.</cite></li>
<li><cite id="CITEREFWiseGillumSeidmanLindor2002" class="citation journal cs1">Wise CA, Gillum JD, Seidman CE, Lindor NM, Veile R, Bashiardes S, Lovett M (2002). <a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fhmg%2F11.8.961">"Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder"</a>. <i>Hum. Mol. Genet</i>. <b>11</b> (8): <span class="nowrap">961–</span>9. <a href="CiteSeerX_(identifier)" class="mw-redirect" title="CiteSeerX (identifier)">CiteSeerX</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.588.1632">10.1.1.588.1632</a></span>. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fhmg%2F11.8.961">10.1093/hmg/11.8.961</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11971877">11971877</a>.</cite></li>
<li><cite id="CITEREFBadourZhangShiMcGavin2003" class="citation journal cs1">Badour K, Zhang J, Shi F, McGavin MK, Rampersad V, Hardy LA, Field D, Siminovitch KA (2003). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS1074-7613%2802%2900516-2">"The Wiskott–Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse"</a>. <i>Immunity</i>. <b>18</b> (1): <span class="nowrap">141–</span>54. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS1074-7613%2802%2900516-2">10.1016/S1074-7613(02)00516-2</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12530983">12530983</a>.</cite></li>
<li><cite id="CITEREFShohamCentolaMansfieldHull2003" class="citation journal cs1">Shoham NG, Centola M, Mansfield E, Hull KM, Wood G, Wise CA, Kastner DL (2003). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC263843">"Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway"</a>. <i>Proc. Natl. Acad. Sci. U.S.A</i>. <b>100</b> (23): <span class="nowrap">13501–</span>6. <a href="Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2003PNAS..10013501S">2003PNAS..10013501S</a>. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.2135380100">10.1073/pnas.2135380100</a></span>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC263843">263843</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14595024">14595024</a>.</cite></li>
<li><cite id="CITEREFRualVenkatesanHaoHirozane-Kishikawa2005" class="citation journal cs1">Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". <i>Nature</i>. <b>437</b> (7062): <span class="nowrap">1173–</span>8. <a href="Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2005Natur.437.1173R">2005Natur.437.1173R</a>. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fnature04209">10.1038/nature04209</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16189514">16189514</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:4427026">4427026</a>.</cite></li>
<li><cite id="CITEREFBaumKirkinFernándezPick2005" class="citation journal cs1">Baum W, Kirkin V, Fernández SB, Pick R, Lettau M, Janssen O, Zörnig M (2005). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M502222200">"Binding of the intracellular Fas ligand (FasL) domain to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL"</a>. <i>J. Biol. Chem</i>. <b>280</b> (48): <span class="nowrap">40012–</span>24. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M502222200">10.1074/jbc.M502222200</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16204241">16204241</a>.</cite></li>
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<div class="gallerytext"><b>2dil</b>: Solution structure of the SH3 domain of the human Proline-serine-threonine phosphatase-interacting protein 1</div>
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This article is issued from <a class="external text" title="Last edited on 2025-07-17" href="https://en.wikipedia.org/wiki/?title=PSTPIP1&oldid=1301024864">Wikipedia</a>. The text is available under <a class="external text" href="https://creativecommons.org/licenses/by-sa/4.0/deed.en">Creative Commons Attribution-Share Alike 4.0</a> unless otherwise noted. Additional terms may apply for the media files.
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